Chiara Anania 764 Accesses, 1 Altmetric Abstract In an era when half a yeast genome can be made of synthetic DNA, the synthesis of a complete mammalian genome remains challenging. To help overcome this…
A global view of aging and Alzheimer’s pathogenesis-associated cell population dynamics and molecular signatures in human and mouse brains
Andras Sziraki, Ziyu Lu, Jasper Lee, Gabor Banyai, Sonya Anderson, Abdulraouf Abdulraouf, Eli Metzner, Andrew Liao, Jason Banfelder, Alexander Epstein, Chloe Schaefer, Zihan Xu, Zehao Zhang, Li Gan, Peter T. Nelson, Wei…
Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis
Alan P. Tenney, Silvio Alessandro Di Gioia, Bryn D. Webb, Wai-Man Chan, Elke de Boer, Sarah J. Garnai, Brenda J. Barry, Tammy Ray, Michael Kosicki, Caroline D. Robson, Zhongyang Zhang, Thomas E….
Rare coding variants in CHRNB2 reduce the likelihood of smoking
Veera M. Rajagopal, Kyoko Watanabe, Joelle Mbatchou, Ariane Ayer, Peter Quon, Deepika Sharma, Michael D. Kessler, Kavita Praveen, Sahar Gelfman, Neelroop Parikshak, Jacqueline M. Otto, Suying Bao, Shek Man Chim, Elias Pavlopoulos,…
Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis
Abhishek Sampath Kumar, Luyi Tian, Adriano Bolondi, Amèlia Aragonés Hernández, Robert Stickels, Helene Kretzmer, Evan Murray, Lars Wittler, Maria Walther, Gabriel Barakat, Leah Haut, Yechiel Elkabetz, Evan Z. Macosko, Léo Guignard, Fei…
G4access identifies G-quadruplexes and their associations with open chromatin and imprinting control regions
Cyril Esnault, Talha Magat, Amal Zine El Aabidine, Encar Garcia-Oliver, Anne Cucchiarini, Soumya Bouchouika, David Lleres, Lutz Goerke, Yu Luo, Daniela Verga, Laurent Lacroix, Robert Feil, Salvatore Spicuglia, Jean-Louis Mergny & Jean-Christophe…
Elisa-AVePGM: An Allergen-Mediated and Viral Gene Transfection Technique to Modifying Pathogenic Mutations
Alessio Rosario Marte 1702 Accesses, 4 Citations, 395 Altmetric Abstract Immunogenetics, as a branch of science, explores the genetic determinants underlying immune phenomena and the mechanisms by which the immune system shapes…
Potent and uniform fetal hemoglobin induction via base editing
Thiyagaraj Mayuranathan, Gregory A. Newby, Ruopeng Feng, Yu Yao, Kalin D. Mayberry, Cicera R. Lazzarotto, Yichao Li, Rachel M. Levine, Nikitha Nimmagadda, Erin Dempsey, Guolian Kang, Shaina N. Porter, Phillip A. Doerfler,…
Accurate rare variant phasing of whole-genome and whole-exome sequencing data in the UK Biobank
Robin J. Hofmeister, Diogo M. Ribeiro, Simone Rubinacci & Olivier Delaneau 3309 Accesses, 68 Altmetric AbstractPhasing involves distinguishing the two parentally inherited copies of each chromosome into haplotypes. Here, we introduce SHAPEIT5,…
Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells
Caleb A. Lareau, Sonia M. Dubois, Frank A. Buquicchio, Yu-Hsin Hsieh, Kopal Garg, Pauline Kautz, Lena Nitsch, Samantha D. Praktiknjo, Patrick Maschmeyer, Jeffrey M. Verboon, Jacob C. Gutierrez, Yajie Yin, Evgenij Fiskin,…